| Name | Status | Role | Fate |
|---|---|---|---|
| Offred | Alive | Handmaid | Serve the Waterford family as a handmaid. |
| Luke | Deceased | Husband | Killed while trying to help June and Hannah escape to Canada. |
| Moira | Deceased | Handmaid | Killed by Gilead. |
| Serena Joy Waterford | Alive | Wife | Fulfill wife duties in the Republic of Gilead; must bear children via Offred. |
| Fred Waterford | Alive | Commander | Lead the Republic of Gilead; use Offred to bear children, as his wife is unable to. |
| Aunt Lydia | Alive | Aunt | Train handmaids at the Rachel and Leah Center. |
| Rita | Alive | Martha | Serve the Waterford family as a Martha. |
| Nick | Alive | Driver | Serve the Waterford family as a driver. |
| Ofglen | Alive | Handmaid | Be Offred's shopping companion. |
| Ofwarren | Alive | Handmaid | Aunt Lydia plucked her right eye out for speaking out of turn; pregnant with her Commander's child. |
| Ofrobert | Alive | Handmaid | Serve her Commander, who is unable to "perform" the ceremony. |
| Ofglen 2 | Alive | Handmaid | Replace Ofglen 1. |